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Thread: Antidepressant drug could be key to beating prostate cancer

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    Antidepressant drug could be key to beating prostate cancer

    Antidepressants could be key to beating prostate cancer, experts have revealed.
    They found an “old” drug helped stop the disease spreading to the bones – a major cause of death in those men diagnosed with the most common form of male cancer.
    In nine out of 10 fatal cases of prostate cancer, the disease spreads to the bones.
    Now, a team of scientists believe they have discovered exactly how the cancer cells are able to hijack the body’s bone maintenance system.
    Having made the discovery, Dr. Jason Wu, and his team at Washington State University found a known antidepressant drug, used in research, can halt the process.
    “Our findings provide a rationale to pursue the use of these ‘old’ antidepressant drugs to benefit late-stage prostate cancer patients with signs and symptoms of metastasis,” he said.
    Prostate cancer is the most common form of the disease in men, and more than 47,000 cases are diagnosed every year in the UK – that’s 130 men a day, according to Prostate Cancer UK.
    One in eight men will get the disease in their lifetime, and more than 11,000 lose their lives each year to the disease.
    The researchers infected mice with human prostate cancer cells.
    They were then able to identify an enzyme called MAOA, which set in motion a series of events that makes it easier for diseased cells to invade and grow in bone.
    They used several strains of human cancer in the mice, and noticed the same results.
    “When we reduced this enzyme expression in prostate cancer cells, we found a lower prostate cancer bone metastasis,” Wu said.
    “On the other hand, if we over express this enzyme in prostate cancer cells, we found increased bone metastasis in mice.”
    Metastasis is the medical word to describe when cancer has spread.
    Wu’s team then tested the effect of a drug called clorgyline.
    The drug stopped the enzyme signalling – the process that allows cancer cells to invade and spread.
    Similar drugs are used clinically as antidepressants, Wu and his team noted.
    He added: “To be sure, there have been no clinical studies reporting a lower risk of prostate cancer in people currently taking antidepressants.

    http://nypost.com/2017/03/14/antidep...ostate-cancer/
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    waltky (04-12-2017)

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    Red face

    Recommendation on Prostate Cancer Screening Changing...

    US Panel Changes Recommendation on Prostate Cancer Screening
    April 11, 2017 - An independent U.S. panel of experts has changed course on its recommendation against routine PSA screening of men for prostate cancer.
    In a draft recommendation, the U.S. Preventive Services Task Force said men between the ages of 55 and 69 should be screened using the prostate-specific antigen test on an "individualized" basis. The panel concluded, in its new guidance, that the potential benefits of screening slightly outweighed the harm. The new draft guidelines echo those of several leading medical groups, but they don't make the decision any easier for men: With their doctor's help, they have to decide whether to take an imperfect PSA test that carries a small chance of detecting a deadly cancer and a larger chance of triggering unneeded worry and treatment with serious side effects.


    "This isn't a one-size-fits-all" recommendation, said the panel's chair, Dr. Kirsten Bibbins-Domingo, a San Francisco internist who already follows the advice and discusses the potential pros and cons with her patients. Men whose greatest concern is reducing their chances of dying from cancer are sometimes willing to face the consequences and choose testing. "Other men will realize the likely benefit is small and aren't willing to risk the harms," she said.


    Controversial call


    In a 2012 recommendation that caused controversy within the medical community, the task force expressed concern that routine use of the PSA test was leading to unnecessary biopsies and other tests in men suspected of having prostate cancer. Critics of that recommendation worried that as a result of any reduction in testing, prostate cancer might be diagnosed at a more advanced stage in some men.



    Dr. Kirsten Bibbins-Domingo poses at her office in San Francisco, April 7, 2017. Draft recommendations from the U.S. Preventive Services Task Force ditch the old advice against PSA screening and say whether to get tested should be left up to men aged aged 55 to 69 after being informed of the potential benefits and harms.



    According to new data released by the task force, the test would let three men out of 1,000 avoid metastatic cancer and would prevent one to two prostate cancer deaths in 1,000. The revised guidance is based on the findings of the European Randomized Study of Screening for Prostate Cancer. A longer follow-up period revealed that slightly more men in the 55-69 age group benefited from screening when the disease was suspected.


    'Thoughtful' policy


    The American Urological Association is hailing the proposed new recommendation as "thoughtful and reasonable." But the association expressed concern that, under the guidelines, men 70 and older would not be screened for prostate cancer. A statement issued by the association said, "We believe that selected older healthier men may garner a benefit from prostate cancer screening," even though the group acknowledged there is limited evidence that men in this age group benefit from the PSA test.


    The revised draft recommendation is open to public comment before a final recommendation is issued. The U.S. Preventive Services Task Force is a national independent volunteer panel of medical experts created in 1984. It is funded, staffed and appointed by an agency of the U.S. Department of Health and Human Services. The task force is charged with making "evidence-based" recommendations about clinical preventive services, including health screenings, counseling services and preventive medications.


    http://www.voanews.com/a/protate-can...s/3805549.html

    Uncle Ferd says, "Hey, wait a minute - she ain't got no prostate."

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    I went to the Urologist yesterday got the yearly UGH test and he gave me the results of the blood test. He said I dont need any more PSA tests, its extremely unlikely I will ever contract prostrate cancer.
    LETS GO BRANDON
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    waltky (06-07-2017)

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    Red face

    Granny tells possum dat if he keeps doin' dat - he gonna get prostate cancer...

    Prostate cancer breakthrough could cut deaths by 40 per cent, double life expectancy, British trial suggests
    Tuesday 6th June, 2017 — Scientists are hailing a breakthrough treatment for prostate cancer that promises hope for more than 20,000 men after proving it could slash deaths by almost 40 per cent.
    The results from a major British-run trial suggest adding the controversial drug abiraterone to standard hormone therapy will double life expectancy in those with the most advanced form of the disease and “effectively cure” it in many less critical patients. Men whose prostate cancer has spread can currently expect to survive around 3.5 years. However, under the new strategy this is expected to become seven years. It also cuts by 50 per cent the traumatic bone complications that often accompany late-stage prostate cancer. The results, announced at the American Association of Clinical Oncology conference in Chicago, are relevant to roughly half the 40,000 men who have prostate cancer diagnosed in England each year.

    Currently health chiefs only prescribe abiraterone to patients where the disease has spread and who are no longer responding to standard treatment. But in the new 2,000-patient trial, believed to be the largest of its kind ever, doctors combined the hormone regime, known as androgen deprivation therapy, alongside abiraterone in the first instance. Androgen deprivation therapy slows prostate cancer by preventing testicles from producing testosterone and other similar hormones that fuel tumour growth, but it cannot prevent other glands such as the prostate from continuing to make them. By contrast, abiraterone is able to stop the production of both testosterone and other androgens throughout the body by targeting the crucial enzyme that converts the hormones.


    A surgeon in Lyon, France conducts prostate cancer surgery. A newly published Canadian study suggests that having advanced male-pattern baldness strongly predicts risk of prostate cancer.

    It’s a once-in-a-career feeling

    “These are the most powerful results I’ve seen from a prostate cancer trial — it’s a once-in-a-career feeling,” said Nicholas James, chief investigator on the Cancer Research UK-funded trial. “This is one of the biggest reductions in death I’ve seen in any clinical trial for adult cancers.”

    Around half the men who have prostate cancer diagnosed are not immediately prescribed any treatment — instead, their slow-growing tumours are regularly monitored as part of a “watch and wait” strategy. But of around 20,000 men in England who do require immediate treatment, 5,000 are diagnosed when the disease cannot be cured. Another 5,000 patients whose cancer mestastises die a year after diagnosis. Prof James, professor of clinical oncology at Birmingham University, said the projection of seven years’ life expectancy with abiraterone was “enormously exciting”.

    http://news.nationalpost.com/news/wo...-+Top+Stories)
    Last edited by waltky; 06-07-2017 at 01:13 AM.

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    Exclamation

    Prostate cancer deaths overtaking deaths from breast cancer...

    Prostate cancer deaths overtake those from breast cancer
    2 February 2018 - The number of men dying from prostate cancer has overtaken female deaths from breast cancer for the first time in the UK, figures show.
    An ageing population means more men are developing and dying from the disease. Prostate Cancer UK says advances in the diagnosis and treatment of breast cancer are paying off, and increased funding could benefit prostate cancer. The biggest cancer killers in the UK remain lung and bowel cancer, with prostate now in third place. The latest figures from 2015 show there were 11,819 deaths from prostate cancer compared with 11,442 from breast cancer. Although deaths from prostate cancer have been rising over the past 10 years or so, the mortality rate or the proportion of men dying from the disease has fallen - by 6% - between 2010 and 2015. For breast cancer the mortality rate has come down by 10%, meaning deaths in women are declining more quickly.


    Gary Pettit was 43 when he was diagnosed with prostate cancer, five years ago, after a routine medical through work. He had no symptoms - only an abnormally high PSA (prostate-specific antigen) blood test, which led to further tests and biopsies. Within weeks, he had a seven-hour operation at the Royal Marsden in London to remove the cancer. "I'm a lucky boy. I stored my sperm before the op and now we've got a little seven-month-old miracle baby, called Teddy. I can't say how lucky I've been." Gary says recovering from the surgery took quite a while and there were some side-effects which he is still getting used to - but he is clear of cancer and keen to raise awareness among other men. "It is still a taboo subject with men. They get shy and embarrassed, but it's so important to get checked out."

    'Tremendous progress'

    Angela Culhane, chief executive of the charity Prostate Cancer UK, said the disease currently received half the funding and half the research that is devoted to breast cancer. She said developing better diagnostic tests that could be used as part of a nationwide screening programme would be a priority. At present, there is no single, reliable test for prostate cancer - the PSA test, biopsies and physical examinations are all used. Men with prostate cancer can also live for decades without symptoms or needing treatment because the disease often progresses very slowly.

    What are the symptoms?

    There can be few symptoms of prostate cancer in the early stages, and because of its location most symptoms are linked to urination:

    * needing to urinate more often, especially at night
    * needing to run to the toilet
    * difficulty in starting to urinate
    * weak urine flow or taking a long time while urinating
    * feeling your bladder has not emptied fully

    Men with male relatives who have had prostate cancer, black men and men over 50 are at higher risk of getting the disease. Ms Culhane said: "It's incredibly encouraging to see the tremendous progress that has been made in breast cancer over recent years. "The introduction of precision medicine, a screening programme and a weighty research boost has no doubt played an important role in reducing the number of women who die from the disease. "The good news is that many of these developments could be applied to prostate cancer and we're confident that with the right funding, we can dramatically reduce deaths within the next decade."

    Living longer

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    Quote Originally Posted by waltky View Post
    Prostate cancer deaths overtaking deaths from breast cancer...

    Prostate cancer deaths overtake those from breast cancer
    2 February 2018 - The number of men dying from prostate cancer has overtaken female deaths from breast cancer for the first time in the UK, figures show.
    Not so long ago the common belief about prostrate cancer was that you died of something else or old age before prostrate cancer got you- for most men. Some had a very aggressive type.
    ΜOΛΩΝ ΛΑΒΕ


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    Quote Originally Posted by Peter1469 View Post
    Not so long ago the common belief about prostrate cancer was that you died of something else or old age before prostrate cancer got you- for most men. Some had a very aggressive type.
    Men are living longer. Of course there's a higher chance of dying form...anything.

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