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Thread: Stem cell research

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    waltky's Avatar Senior Member
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    Stem cell research

    Restoring fertility with stem cells...

    Stem cell op may 'restore sperm'
    1 November 2012 - Boys left infertile by childhood cancer treatment may one day be able to produce healthy sperm by using stored stem cells, monkey research suggests.

    Chemotherapy and radiotherapy can kill tumours and the cells which make sperm. A study, published in the journal Cell Stem Cell, extracted sperm-producing stem cells before cancer treatment and later placed them back into the monkey. Sperm which could fertilise an egg were produced, which experts labelled a "milestone" in research. Most men who have cancer treatment which could affect their fertility can choose to freeze sperm before their treatment starts. This is not an option for patients who have not yet gone through puberty. However, they do have the spermatogonial stem cells which would start to produce sperm in their teenage years.

    The researchers at the University of Pittsburgh and the Magee-Womens Research Institute took samples of the stem cells from macaques and stored them in a freezer. The monkeys were then given a chemotherapy drug. Their own stem cells were implanted back where they came from after the course of chemotherapy had ended. Nine out of 12 adult monkeys and three out of five prepubescent monkeys were later able to produce sperm again. Separate experiments showed eggs could be fertilised with sperm produced after the procedure.

    'Feasible'

    Dr Kyle Orwig, from the department of obstetrics, gynaecology and reproductive medicine at Pitt School of Medicine, said: "This study demonstrates that spermatogonial stem cells from higher primates can be frozen and thawed without losing their activity, and that they can be transplanted to produce functional sperm that are able to fertilise eggs and give rise to early embryos." He said there were still many challenges before this could be used in people: "Should we re-introduce the spermatogonial cells as soon as treatment is over, or wait until the patient is considered cured of his disease, or when he is ready to start a family? How do we eliminate the risk of cancer recurrence if we give back untreated cells that might include cancer cells?

    "These are issues we still must work through, but this study does show us the concept is feasible. Dr Allan Pacey, senior lecturer in andrology at the University of Sheffield, told the BBC that the idea had been discussed repeatedly but "experiments have never come close to suggesting it might work in humans". However, he said: "This report is a very useful step forward and clearly shows that the science of spermatogonial stem cells transplantation might one day work for humans. And, although the authors report relatively low efficiency so far, in the context of someone who does not have any banked sperm to fall back on, these odds are probably very encouraging to make this kind of approach worthwhile."

    More http://www.bbc.co.uk/news/health-20168914

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    Calypso Jones's Avatar Banned
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    You posted this so obviously you think it's very important. Why?

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    waltky's Avatar Senior Member
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    No disrespect but...

    ... it should be obvious.

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    Their own stem cells were implanted back where they came from after the course of chemotherapy had ended.
    I don't see how this could be controversial at all

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    Quote Originally Posted by Conley View Post
    I don't see how this could be controversial at all
    "Stem cells" is one of those RWNJ buzz terms that immediately produces a knee-jerk reaction whenever mentioned.
    my junk is ugly

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    Quote Originally Posted by Captain Obvious View Post
    "Stem cells" is one of those RWNJ buzz terms that immediately produces a knee-jerk reaction whenever mentioned.
    Not really, if it is left over from an abortion why not try but adult stem cells are better. But we don't want labs making babies just to kill them. Also, even in China many implanted human embryonic stem cells into a suffering Parkinson's patient's brain only to have them transform into a powerful tumor that eventually killed them, others no change and some got worse.
    But no real controversial topics on adult stem cells. They can and have been shown to help and produce skeletal muscle, neural, cardiac muscle, and liver cells and help circulatory system in response to tissue damage.

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    Fetal stem cells have had bad results. They start growing and don't stop.

    Your own stem cells- programed to do a specific task holds much promise.

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    Am interested in any links that show bad results with fetal stem cells...

    ...was not aware that there is a problem with them...

    ... and thanks for bringing this to my attention.

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    Quote Originally Posted by Calypso Jones View Post
    You posted this so obviously you think it's very important. Why?

    Your inability to handle simple logic is truly magnificent .
    The OP published in the Health and Medicine Room .
    What a silly boy . He should have published it in The Sports Section .
    He published it because he thought it interesting and relevant , presumably .
    He made no mention of it being , very important -- though it might well be . Guess you have made a , Romney --- as all redundant people might now become known .


    Infraction issued
    Last edited by Captain Obvious; 11-06-2012 at 06:18 PM.

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    Quote Originally Posted by waltky View Post
    Am interested in any links that show bad results with fetal stem cells...

    ...was not aware that there is a problem with them...

    ... and thanks for bringing this to my attention.
    I will try to find something when I get back from work.

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