What the Repubs are doing is not working. I think a true conservative would have had a better chance than a liberal Mormon Yankee from Massachusetts -- there would have been a more obvious difference between the two candidates.
The Repubs -- maybe not Mitt himself -- keep alienating women and minorities. That makes it a lot harder to win. There's a lot Americans agree on but the bozos on the left and the right prefer to focus on wedge issues that don't affect most.
Tea Party(ies) candidates did better than big government GOPers.
But, in general, I think demographics have doomed federalism and limited federal government ideas. The only thing left is collapse..., and then re-birth.