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    Lightbulb Alzheimer's & dementia

    New study shows way to detect Alzheimer's earlier...

    Alzheimer's detected decades before symptoms
    5 November 2012 - Researchers have found some of the earliest signs of Alzheimer's disease, more than two decades before the first symptoms usually appear.
    Treating the disease early is thought to be vital to prevent damage to memory and thinking. A study, published in the Lancet Neurology, found differences in the brains of an extended Colombian family predisposed to develop an early form of Alzheimer's. Experts said the US study may give doctors more time to treat people. Alzheimer's disease starts long before anyone would notice; previous studies have shown an effect on the brain 10-15 years before symptoms.


    The shrunken brain of an Alzheimer's patient compared with a healthy one

    It is only after enough brain cells have died that the signs of dementia begin to appear - some regions of the brain will have lost up to 20% of their brain cells before the disease becomes noticeable. However, doctors fear so much of the brain will have degenerated by this time that it will be too late to treat patients. The failure of recent trials to prevent further cognitive decline in patients with mild to moderate Alzheimer's disease has been partly put down to timing.

    Early start

    A team at the Banner Alzheimer's Institute in Arizona looked at a group of patients in Colombia who have familial Alzheimer's. A genetic mutation means they nearly always get the disease in their 40s. Alzheimer's normally becomes apparent after the age of 75. Brain scans of 20 people with the mutation, aged between 18 and 26, already showed differences compared with those from 24 people who were not destined to develop early Alzheimer's. The fluid which bathes the brain and spinal cord also had higher levels of a protein called beta-amyloid.

    The researchers said differences could be detected "more than two decades before" symptoms would appear in these high-risk patients. Dr Eric Reiman, one of the scientists involved, said: "These findings suggest that brain changes begin many years before the clinical onset of Alzheimer's disease. "They raise new questions about the earliest brain changes involved in the predisposition to Alzheimer's and the extent to which they could be targeted by future prevention therapies."

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    Thanks for posting. Good information for the conservative posters on the forum.

    Got anything on Romneysia?

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    Captain Obvious's Avatar Senior Member
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    Quote Originally Posted by GrumpyDog View Post
    Thanks for posting. Good information for the conservative posters on the forum.

    Got anything on Romneysia?
    Please keep to the topic

    http://thepoliticalforums.com/thread...litical-Forums


    Other Discussions are for more serious discussion and stricter moderation. The rules apply but, on the positive side, we will also require that all posts make a contribution be it information, question or argumentation, and on the negative side we will not allow trolling, inflammatory remarks, personal attacks, or off-topic comments.
    my junk is ugly

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    Lightbulb

    Treating tau bundles in Alzheimer's patients...

    New Drug Takes on Alzheimer’s by Sweeping for Protein Clumps
    January 25, 2017 - Scientists have developed a drug they hope will benefit people with Alzheimer’s disease, which afflicts an estimated 44 million people around the world. The new compound sweeps away abnormal protein clumps in the brain which are a hallmark of the neurodegenerative disorder.
    In a study reported in the journal Science Translational Medicine, researchers describe how a synthetic drug, called antisense oligoneucleotide, reduced the production and in some cases cleared clumps of tau in the brain. Tau bundles are one of the hallmarks of the disease, along with beta amyloid deposits, another destructive protein. By stopping the formation of tau, researchers at Washington University School of Medicine in St. Louis, Missouri, found they could extend the lives of mice that were bred to have collections of human tau in their brains.


    An image shows activity in a human brain. Scientists have developed a drug capable of sweeping away abnormal protein clumps in the brain which are a hallmark of Alzheimer’s disease.

    Lead author Sara DeVos said scientists saw an improvement in their condition. “So these mice die earlier than normal. So when we treat with our drug, the mice live longer and we can also prevent neurons from dying. So if we give this drug, the neurons will no longer die as a result of these tau bundles,” said DeVos The investigators also tested the compound in monkeys and saw positive results.

    Human testing expected soon

    Antisense oligneucleotide targets the genetic instructions for building tau. The molecule binds to messenger RNA, which carries out the DNA blueprint for life, preventing tau from being produced. The drug can be made to target RNA for destruction of any protein, said scientists. Tim Miller, a professor of neurology at Washington University and senior author of the study, hopes the drug, developed with Ionis Pharmaceuticals, will soon be tested in humans with Alzheimer’s disease. “The most exciting and most interesting ... is to apply this to people who we presume have abnormal tau to test the hypothesis whether lowering tau in those people will be of benefit to those people,” he said.


    Patients with Alzheimer's and dementia are seen during a therapy session. Alzheimer's afflicts an estimated 44 million people around the world.

    Other types of antisense oligoneucleotides have been approved by U.S. regulators and are being used to treat the neurodegenerative disease muscular dystrophy and spinal muscular atrophy. The compound is in clinical trials for Huntington’s disease and ALS, also known as Lou Gehrig’s disease. Because tau deposits are only a piece of the puzzle that causes Alzheimer’s, the investigators envision using the drug with other treatments, also in development. There is no cure for Alzheimer’s disease, which primarily strikes senior adults, leading to a decline in mental functioning and eventually death.

    http://www.voanews.com/a/protein-swe...g/3692736.html

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    I kind of laughed when I saw this since I have found myself frequently arguing the many benefits of hormonal contraception, which now also apparently could include some protection against Alzheimer's and other conditions which affect cognitive functioning:

    Longer Use of Hormonal Contraception During Midlife Predicts Better Cognitive Function Later

    ScienceDaily (Nov. 7, 2012) — Premenopausal use of hormonal contraceptives may improve the cognitive abilities of women in midlife and for years afterward. This finding may have implications for prevention of declining cognitive function that occurs with advancing age and in diseases such as Alzheimer's. The beneficial effects of hormones increase the longer a woman uses them, as described in a study published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.
    http://www.sciencedaily.com/releases...1107122602.htm

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    Trinnity's Avatar Banned
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    I have heard there is research suggesting NOT eating meat contributes to Alzheimer's. It would be (literally) ironic if strict vegetarianism increased one's chances for the disease (no snark intended). I mean eating a lot of vegetables is definitely very healthy overall. Maybe deep down in ways we don't yet understand, man/woman is meant to consume some meat.

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    Quote Originally Posted by Trinnity View Post
    I have heard there is research suggesting NOT eating meat contributes to Alzheimer's. It would be (literally) ironic if strict vegetarianism increased one's chances for the disease (no snark intended). I mean eating a lot of vegetables is definitely very healthy overall. Maybe deep down in ways we don't yet understand, man/woman is meant to consume some meat.

    Right. You need high quality Omega 3s to protect the CPU. You aren't getting that from non-meat sources.

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    Quote Originally Posted by Peter1469 View Post
    Right. You need high quality Omega 3s to protect the CPU. You aren't getting that from non-meat sources.
    What makes meat a high quality source of Omega 3 but not plant sources? I've never heard of that before. Animals get their Omega 3s from eating plants or from eating other animals that have eaten plants.
    Therefore I'm skeptical of where the research comes from stating that the best place to get Omega 3s is from meat.

    Good plant sources of Omega 3s:

    Flax seeds
    Chia seeds
    Beans
    Winter squash
    Leafy greens
    Vegetables in the cabbage family
    Berries
    Wild rice
    Mangoes
    Honeydew Melon

    In order to be healthy, it's very important for Omega 3s to get converted to DHA and EPA in the body. However, high levels of Omega 6 will inhibit the conversion process. And animal sources of Omega 3, more often than not, are much higher in Omega 6 than Omega 3.
    Last edited by Trumpster; 01-05-2017 at 05:27 PM.

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    Angry

    Will also affect Parkinson's research...

    Pharma giant Pfizer pulls out of research into Alzheimer's
    10 January 2018 - Drug company Pfizer has announced it is pulling out of research into drugs to treat Alzheimer's disease.
    The US-based pharmaceutical giant said it would be ending its neuroscience discovery programmes following a review, and 300 jobs would be lost. The Alzheimer's Society called the news "disappointing" and a "heavy blow" to those living with dementia. Companies should be encouraged to invest in research into neuroscience, Alzheimer's Research UK said. The move means Pfizer will also stop looking for treatments for Parkinson's disease, but the company said it planned to create a new fund dedicated to neuroscience research in the future. A statement from the company said: "We have made the decision to end our neuroscience discovery and early development efforts and re-allocate funding to those areas where we have strong scientific leadership and that will allow us to provide the greatest impact for patients."

    Complex brain

    Prof Tara Spire-Jones, a neuroscientist at Edinburgh University, told the Today programme on BBC Radio 4 that despite the decision, there was still a lot of hope. "Not all pharmaceutical companies are pulling out and there are over 100 clinical trials at the moment. "There is a lot going on in the basic science - we need to understand the complexity of the brain." She said Pfizer's decision was understandable because of the failure rate of clinical trials. "More than 99% of trials for Alzheimer's drugs have failed in past 15 years. "So companies are justifiably cautious, but we are making great advances on the scientific front."


    Pfizer's decision will affect research into drugs for Alzheimer's and Parkinson's disease

    Prof Spire-Jones added: "We've learned from these failures of trials that we need to take a step back and understand brain changes. "At the moment we don't fully understand how memory and thinking work fully in a healthy brain." Pharmaceutical companies including Novartis, Janssen, Biogen, Abbvie and Eli Lilly are still developing medicines to treat Alzheimer's disease and a spokesman for the ABPI (Association of the British Pharmaceutical Industry) said they continued "to make progress in unravelling the complexities of the brain and identifying the underpinnings of the disease".

    Dr James Pickett, head of research at Alzheimer's Society, said: "Of course it's disappointing to hear that Pfizer, one of the world's leading pharmaceutical companies, will be terminating their research efforts in neuroscience, including Alzheimer's disease drug discovery. "The brain is the most complex organ in the body and developing drugs to treat brain diseases is a tremendous challenge, but with no new drug for dementia in the last 15 years, this will come as a heavy blow to the estimated 46.8 million people currently living with the condition across the globe."

    Long-term commitment

    The Alzheimer's Society said it had committed £50m to fund new research at the UK Dementia Research Institute alongside Alzheimer's Research UK and the Medical Research Council. Dr Matthew Norton, director of policy at Alzheimer's Research UK, said: "We hope that pharmaceutical companies will look at the long-term potential when deciding whether to participate in this effort. "It is vital that all of us - charities, government and industry alike - make long-term commitments to dementia research if we are to bring an end to the fear, harm and heartbreak of dementia." Currently, about 850,000 people in the UK have a form of dementia. One million people are predicted to be living with the condition by 2021, and this could rise to two million by 2051.

    http://www.bbc.com/news/health-42633871

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    Exclamation

    Don't give yer Granny Liquid Laundry Detergent Pods - she might think it's candy...

    Liquid Laundry Detergent Pods Pose Lethal Risk for Adults With Dementia
    June 15, 2017 - One day last May, an 87-year-old woman named Edith was rushed to the hospital in a small Texas town after she was found slumped over and unresponsive at the home where she lived with her son and daughter-in-law. The woman, who suffered from dementia, had eaten two liquid laundry detergent packets. She died two days later.
    Edith’s is one of eight deaths related to ingesting liquid laundry packets in the U.S. between 2012 and early 2017 that have been reported to the Consumer Product Safety Commission. Two of the cases were young children and six were adults with dementia. “Caregivers and children of seniors should be aware that ingestion of the contents of certain liquid laundry packets has led to serious and even tragic incidents,” says Patty Davis, press secretary for the CPSC. “Water, wet hands, and even saliva can dissolve the packets and release the highly concentrated liquid.”


    Liquid laundry detergent packets are squishy like playthings and colorful like candy, which helps explain why children can be drawn to them. Not long after Tide Pods debuted in a television commercial during the Academy Awards in 2012, promoting a new product category, Consumer Reports began calling on manufacturers to make liquid packets safer. CR’s advice to consumers has been to keep laundry packets out of households where children under 6 years old may be present. And although some manufacturers have made some changes to the packaging and the product itself, pods continue to pose serious health risks. Now it’s clear that kids aren’t the only vulnerable population.

    Consumer Reports learned about the pod-related deaths through a Freedom of Information Act request that we filed earlier this year with the CPSC. (CR discovered Edith's name through further reporting but chose to withhold her last name in the interest of her family’s privacy.) According to the information we received from the CPSC, Edith had seemed fine during lunch, just a few hours before she was found. The first clues as to what happened came when her daughter-in-law returned home from the hospital to collect a few things. She found that the pungent smell of laundry detergent filled Edith’s bedroom, and a new container of liquid laundry detergent packets had been opened. Several of the pink pods were missing. Edith, who had been known to mistake objects for candy, had eaten them. The medical examiner ruled her death an accident; ingestion of laundry detergent was listed as the cause.


    Six of the eight deaths, including Edith's, involved pods manufactured by Procter & Gamble, according to the CPSC reports. P&G’s laundry packets are the industry's biggest sellers, with its Tide Pods and sibling brands representing 79 percent of the market, according to IRI, a Chicago-based market research firm. “We are aware of accidental ingestions related to our liquid laundry pacs among adults with previously diagnosed dementia,” Elizabeth Kinney, P&G’s senior communications manager for North America fabric care, told CR. “We are deeply saddened by this and have taken action to understand and help prevent these types of incidents.” Sales of laundry pods totaled $1.2 billion over a recent 12-month period, according to IRI, and accounted for 17 percent of all laundry detergent sales.

    Reported Cases

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