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Thread: Bird, Seasonal & Swine Flu

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    waltky's Avatar Senior Member
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    Red face Bird, Seasonal & Swine Flu

    Brits don't believe Tamiflu works...

    British medical journal slams Roche on Tamiflu
    12 Nov.`12 A leading British medical journal is asking the drug maker Roche to release all its data on Tamiflu, claiming there is no evidence the drug can actually stop the flu.
    The drug has been stockpiled by dozens of governments worldwide in case of a global flu outbreak and was widely used during the 2009 swine flu pandemic. On Monday, one of the researchers linked to the BMJ journal called for European governments to sue Roche. "I suggest we boycott Roche's products until they publish missing Tamiflu data," wrote Peter Gotzsche, leader of the Nordic Cochrane Centre in Copenhagen. He said governments should take legal action against Roche to get the money back that was "needlessly" spent on stockpiling Tamiflu.

    Last year, Tamiflu was included in a list of "essential medicines" by the World Health Organization, a list that often prompts governments or donor agencies to buy the drug. Tamiflu is used to treat both seasonal flu and new flu viruses like bird flu or swine flu. WHO spokesman Gregory Hartl said the agency had enough proof to warrant its use for unusual influenza viruses, like bird flu. "We do have substantive evidence it can stop or hinder progression to severe disease like pneumonia," he said.

    In the U.S., the Centers for Disease Control and Prevention recommends Tamiflu as one of two medications for treating regular flu. The other is GlaxoSmithKline's Relenza. The CDC says such antivirals can shorten the duration of symptoms and reduce the risk of complications and hospitalization. In 2009, the BMJ and researchers at the Nordic Cochrane Centre asked Roche to make all its Tamiflu data available. At the time, Cochrane Centre scientists were commissioned by Britain to evaluate flu drugs. They found no proof that Tamiflu reduced the number of complications in people with influenza. "Despite a public promise to release (internal company reports) for each (Tamiflu) trial...Roche has stonewalled," BMJ editor Fiona Godlee wrote in an editorial last month.

    In a statement, Roche said it had complied with all legal requirements on publishing data and provided Gotzsche and his colleagues with 3,200 pages of information to answer their questions. "Roche has made full clinical study data ... available to national health authorities according to their various requirements, so they can conduct their own analyses," the company said. Roche says it doesn't usually release patient-level data available due to legal or confidentiality constraints. It said it did not provide the requested data to the scientists because they refused to sign a confidentiality agreement. Roche is also being investigated by the European Medicines Agency for not properly reporting side effects, including possible deaths, for 19 drugs including Tamiflu that were used in about 80,000 patients in the U.S.

    http://news.yahoo.com/british-medica...--finance.html

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    Georgia Bulldogs come up with vaccine for multi-strain swine flu...

    Early success in vaccine against multiple strains of influenza
    Wednesday 30th March, 2016 - Sanofi Pasteur, the vaccines division of Sanofi, in collaboration with University of Georgia has developed a vaccine that protects against multiple strains of both seasonal and pandemic H1N1 influenza in mouse models.
    The study, ‘Design and Characterization of a COBRA HA vaccine for H1N1 influenza viruses’, to be presented Wednesday at the World Vaccine Congress US 2016 in Washington, D.C., raises potential for a flu vaccine that covers more than a few strains at a time, and is not affected by the careful guesswork currently used to determine the strains each year's vaccine contains. "One of the problems with current influenza vaccines is that we have to make predictions about which virus strains will be most prevalent every year and build our vaccines around those predictions," said Ted Ross, director of UGA's Center for Vaccines and Immunology and Georgia Research Alliance Eminent Scholar in Infectious Diseases in the College of Veterinary Medicine. "What we have developed is a vaccine that protects against multiple different strains of H1N1 virus at once, so we might be able to one day replace the current standard of care with this more broadly cross-protective vaccine."

    The H1N1 influenza virus caused a worldwide pandemic in 2009. When it was first detected, it was called swine flu because the virus was similar to those found in pigs, but the virus now circulates as a seasonal form of influenza. The study, published in the Journal of Virology, states that the vaccine has been developed using a technique called Computationally Optimized Broadly Reactive Antigen, or COBRA, UGA researchers Donald Carter, Christopher Darby and Bradford Lefoley, along with Ross, created nine prototype synthetic compound vaccines constructed using genetic sequences from multiple influenza virus strains.


    The COBRA vaccines were designed to recognize H1N1 viruses isolated within the last 100 years, but many of the experimental vaccines produced immunity against influenza strains not included in the design. This means that scientists may be able to produce a vaccine that not only protects against recognized seasonal and pandemic influenza strains, but also strains that have yet to be discovered.

    While the newly developed vaccine has only been tested with mice, success in the lab has raised expectation of a universal vaccine being developed at some point in the future. "We still have some work to do before we get a truly universal flu vaccine," said Ross. "But the COBRA vaccine we've developed for H1N1 virus subtypes is a major step in the right direction." The scientists said the strategy for designing and using the vaccines could provide a model for designing much more broad, potentially multi-year protection for people.

    Additionally, the scientists emphasized the need to identify strains posing the greatest threat as the process of stopping, tweaking and restarting production of the vaccine slows down its production. With a broadly-applicable vaccine, it could be produced continuously and more cheaply, while protecting more people from infection. "What we have developed is a vaccine that protects against multiple different strains of H1N1 virus at once, so we might be able to one day replace the current standard of care with this more broadly cross-protective vaccine," said Ross in a statement.

    http://www.bignewsnetwork.com/news/2...s-of-influenza
    Last edited by waltky; 03-30-2016 at 04:48 PM.

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    The flu shot is useless.
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