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    waltky's Avatar Senior Member
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    Lightbulb Diabetes advances, research & treatments

    Parents overlook diabetes signs...

    Parents 'unaware of type 1 diabetes symptoms'
    13 November 2012 - Type 1 diabetes is treated with daily insulin doses
    About 90% of parents are unaware of the four key symptoms of type 1 diabetes in children, a survey suggests. The poll of 1,170 parents, for Diabetes UK, suggests many cases go undetected until the child becomes seriously ill. In the BBC News website Scrubbing Up column, its chief executive says about 2,000 under-18s are diagnosed with the condition in the UK each year. The main signs are tiredness, needing the toilet more, excessive thirst and weight loss.

    An estimated 3.7 million people in the UK have diabetes. Type 1 affects about 10% of them. It appears before the age of 40, usually in childhood. It is treated by daily insulin doses - taken either by injections or via an insulin pump - a healthy diet and regular physical activity Type 2 develops when the body can still make some insulin, but not enough, or when the insulin that is produced does not work properly.

    'Obvious'

    Most of the parents surveyed knew thirstiness and tiredness were warning signs. But only 38% knew passing urine frequently was an indication of type 1 diabetes, while even fewer - 28% - linked weight loss with the condition. The charity says this is one reason why a quarter of children with type 1 diabetes are only diagnosed once they are already seriously ill with diabetic ketoacidosis (DKA), a life threatening condition that needs immediate specialist treatment in hospital. DKA happens when the body is unable to break down glucose because there is too little insulin, and it begins to break down fat instead. This causes a by-product called ketones to build up. DKA can lead to children falling into a coma and can even cause death.

    Diabetes UK is launching a campaign to raise awareness among parents and professionals. Barbara Young, chief executive for Diabetes UK, said: "The symptoms of type 1 diabetes are so obvious and pronounced that there is no reason why every child with the condition cannot be diagnosed straight away. "As well as making parents and those who look after and work with children aware of the symptoms, we need to increase understanding that a child who has any of the four tees needs to be tested straight away. "This is because onset can be so quick that a delay of a matter of hours can be the difference between being diagnosed at the right time and being diagnosed too late."

    http://www.bbc.co.uk/news/health-20313267

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    Quote Originally Posted by waltky View Post
    Parents overlook diabetes signs...

    Parents 'unaware of type 1 diabetes symptoms'
    13 November 2012 - Type 1 diabetes is treated with daily insulin doses
    I developed Type 2 diabetes in my late 50s and advanced quickly to daily insulin injections. It totally sucks to take a shot in the belly every day....I can NOT imagine doing that as a child diagnosed with Type 1. It's a cruel disease....but thankfully, one that you can deal with and live at least somewhat of a normal life with it.

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    Diabetes link to cancer in Asia...


    Study: Diabetes Linked to Cancer in Asia
    March 07, 2017 - Researchers at New York University's School of Medicine found that diabetes increased the risk of cancer death among Asians by an average of 26 percent, a statistic similar in the West.
    Data for the new study drew on an analysis of 770,000 people with Type 2 diabetes throughout East and South Asia. Diabetics were followed for an average of 13 years to see if they developed cancer and what types. During that time more than 37,300 cancer deaths were identified. Yu Chen, an epidemiology professor at the NYU School of Medicine’s Department of Population Health who was the study's lead author, says Asians with Type 2 diabetes are more likely to be diagnosed with rarer cancers than Westerners, including cancers of the liver, thyroid and kidney which was double the risk compared to non-diabetics in Asia.


    There was also a 2.7 percent increased risk of cancer of the endometrium and a 1.7 percent higher risk of breast cancer among diabetic Asians compared to those who were not diabetic. The number of cancers of the gallbladder and bile ducts in Asia were comparable to those in the West, according to Chen. Those sites are closer in the body to the pancreas, where insulin is made.



    A paramedic checks the blood sugar level of a patient at a diabetes clinic in Jakarta, Indonesia



    Chen thinks there may be several mechanisms at work, but data suggests that insulin may in some way stimulate the growth of cancer. “Patients with diabetes that have high levels of insulin, some cancers are very sensitive to insulin, so it may promote the tumor growing,” she said. The findings were published in the journal Diabetologia.


    Chen said the study was undertaken because there's been little research on an association between diabetes and cancer in Asia. She said the research suggests Type 2 diabetes should be added to the list of cancer risk factors, along with diet and cigarette smoking. “Cancer prevention needs to take into account for diabetes the lifestyles related to diabetes – [which] may reduce the risk of diabetes and also cancer,” she said. Chen suggested that diabetics should receive more cancer screenings, in addition to medical interventions to reduce the risk of diabetes overall.


    http://www.voanews.com/a/diabetes-ca...a/3754817.html

    See also:


    Researchers Develop Blood Test to Pinpoint Location of Cancer
    March 07, 2017 - Researchers are developing a blood test that can tell not only whether someone has cancer, but in what organ the tumors are lurking. The test could mean more prompt, potentially life-saving treatment for patients.
    Researchers describe their blood test as a kind of dual authentication process. It is able to detect the presence of dying tumor cells in blood as well as tissue signatures, to signal to clinicians which organ is affected by the cancer. There already are tests that screen for traces of DNA released by dying cancer cells. Such blood tests show promise in the treatment of patients to see how well anti-cancer therapies are working. But researchers at the University of California, San Diego discovered a new clue, using organ-specific DNA signatures, that leads them to the particular organ that is affected.


    The finding makes the new blood test potentially useful as a screening tool in people suspected of having cancer. UC-San Diego bioengineering professor Kun Zhang is senior author of a paper in Nature Genetics about the experimental test. "So when you try to do these kinds of early screening or early detection [tests], these people are healthy. So if you take a blood draw and then you do a test, and you find some signature of cancer, that is not enough because you do not know what to do next," Zhang said. "And so, in this case, we developed a method where we can say whether there is a cancer growing in the body and if the answer is 'Yes,' we can also say something about where does it grow."



    A patient has her blood drawn at Jefferson University Hospital in Philadelphia, Pennsylvania



    The test screens for a DNA signature called a CpG methylation haplotype, which is unique for each tissue in the body. When a cancer grows in an organ, it competes with healthy tissue for nutrients and space, killing off healthy cells, which release their DNA into the bloodstream. The haplotype signatures, identified by the blood test, could tell doctors what cells are being destroyed, and therefore what organ is being invaded by cancer. Zhang says knowing a tumor's location is especially crucial for early detection and treatment.


    Researchers created a database of complete CpG methylation patterns for 10 different normal tissues: the lungs, liver, intestine, colon, brain, pancreas, spleen, stomach, kidney and blood. To put together the genetic marker database, the investigators also analyzed tumor and blood samples of cancer patients. They screened the blood samples of 59 patients with lung or colorectal cancer, comparing those findings to people without cancer. "It could be potentially used as a screening test," Zhang said. "So I think that is the real potential. We need to do a few more rigorous clinical observations before we can get to that point." Zhang envisions eventually using the blood test to look for markers of cancer as part of routine blood work.


    http://www.voanews.com/a/researchers...r/3754822.html
    Last edited by waltky; 03-08-2017 at 12:51 AM.

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    Fortunately Type II can be managed by diet. Unfortunately, docs in America tend to prescribe the wrong diet.

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    Quote Originally Posted by Peter1469 View Post
    Fortunately Type II can be managed by diet. Unfortunately, docs in America tend to prescribe the wrong diet.
    I was pretty advanced already at diagnosis, though bloodwork only 4 months earlier had shown nothing....that's how fast it was moving on me. I was already past the "diet and exercise alone" point, but was on just one pill along with a good diet and exercise program for several months......then that quit working and it skyrocketed from there. Doc gave up and sent me to an endo....now I'm on a combo of one non-insulin injectable plus two pills, plus diet and exercise and holding my own (and off insulin, thank God). I'm always the exception to medical rules

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    Sniffing out hypoglycemia...

    Dogs Trained to Monitor Low Blood Sugar May Save Lives
    May 07, 2018 — Dogs can be trained to sniff out drugs and explosives, so Mark Ruefenacht wondered if their exquisite sense of smell could be used to detect changes in a diabetic’s blood sugar level.
    A near fatal episode prompted the forensic scientist, who’s had diabetes for most of his adult life, to ask that question. In 1999, while he was training a puppy to be a guide dog for the blind, his blood sugar suddenly dropped to a dangerously low level. “More than likely, I had a seizure, from the low blood sugar,” Ruefenacht recalled, as he explained how the puppy kept trying to rouse him. “And he stuck with me and I was able to get my blood sugar up.” That incident made him wonder if dogs could be trained to detect the inherent chemical changes that accompany a drop in blood sugar, called hypoglycemia, then alert their owners.


    Dogs4Diabetics


    Ruefenacht worked with scientists and funded research which determined that the “smell” of hypoglycemia shows up in both breath and sweat. He also worked with and studied professionals who train dogs to sniff out everything from explosives to cancer. And most important of all, Ruefenacht started training a fun-loving yellow Labrador retriever named Armstrong to alert him when he was having a dangerously low blood sugar. The training proved so successful, Armstrong is listed in the Guinness Book of World Records as the first diabetes-detection dog. Sitting under a poster of Armstrong, who died in 2012, Ruefenacht recalls that those early successes led some organizations to offer him large sums of money for the rights to his discoveries. Ruefenacht says he turned those opportunities down. Instead, in 2004, he founded Dogs4Diabetics. He says properly training a diabetes detection dog and its owner can cost $50,000. The organization raises money to cover these expenses, then provides the dogs at no cost to people who qualify.


    The smell of hypoglycemia


    The dogs are trained to identify the scent of hypoglycemia on a reliable and consistent basis. Ruefenacht uses jars containing swabs of sweat from a diabetic who had low blood sugar, randomly mixed with jars of other distracting smells, such as peanut butter, dog food and eucalyputus. The dogs are rewarded when they select the correct jar. This "sweat jar" method for training diabetes alert dogs has been validated scientifically. The next step is to teach them to alert their owner. The dogs are trained to use subtle signals, but if those go unnoticed, to put their paws on his lap, or balance on their back legs and put their front paws on his shoulders. They learn to snuffle at his nose and mouth, lick his face and bark. And if all else fails, they’re trained to get someone else to come and help.



    Mark Ruefenacht and Armstrong, the first diabetes alert dog.


    Ruefenacht says the dogs are often aware of blood sugar drops long before electronic monitoring systems send a warning alarm. Dogs4Diabetics has placed more than 100 dogs with diabetics. They hope to expand the program - training humanity's most loyal companion to save lives and help diabetics around the world.


    https://www.voanews.com/a/dogs-for-d...s/4382782.html

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    Once again glad to be in the Canadian system. Was diagnosed in June, saw an endo 2 weeks later and went through the training. No meds, just diet, fruits, veggies and fiber.

    So far, so good


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    Diabetes epidemic 'marches on'...

    Deadly diabetes in 'unrelenting march'
    Wed, 06 Apr 2016 - The world is facing an "unrelenting march" of diabetes which now affects one in 11 people, the World Health Organization warns.
    In a major report it warned cases had nearly quadrupled to 422 million in 2014 from 108 million in 1980. High blood sugar levels are a major killer - linked to 3.7 million deaths around the world each year, it says. And officials said the numbers would continue to increase unless "drastic action" was taken. The report lumps both type 1 and type 2 diabetes together, but the surge in cases is predominantly down to type 2 - the form closely linked to poor lifestyle.


    As the world's waistlines have ballooned - with one-in-three people now overweight, so too has the number of diabetes cases. Dr Etienne Krug, the WHO official in charge of leading efforts against diabetes, told the BBC: "Diabetes is a silent disease, but it is on an unrelenting march that we need to stop. "We can stop it, we know what needs to be done, but we cannot let it evolve like it does because it has a huge impact on people's health, on families and on society."

    Failing to control levels of sugar in the blood has devastating health consequences. It triples the risk of a heart attack and leaves people 20 times more likely to have a leg amputated, as well as increasing the risk of stroke, kidney failure, blindness and complications in pregnancy. Diabetes itself is the eighth biggest killer in the world, accounting for 1.5 million deaths each year. But a further 2.2 million deaths are linked to high blood sugar levels. And 43% of the deaths were before the age of 70.

    Moving burden

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    Diabetes used to be called sugar diabetes. Type II diabetes is 100% bad lifestyle choices. It is 100% reversible until you blow it off long enough for your body to break down too much to be fixed. Then you die.
    ΜOΛΩΝ ΛΑΒΕ


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    Quote Originally Posted by Peter1469 View Post
    Diabetes used to be called sugar diabetes. Type II diabetes is 100% bad lifestyle choices. It is 100% reversible until you blow it off long enough for your body to break down too much to be fixed. Then you die.
    That's my Dad unfortunately.

    Old school construction worker, self made millionaire, didn't believe in anything but himself.

    His eyes started going first which changed his mind on doctors quickly however it was already too late. His kidneys are toast now. Dialysis 4 days a week and has had 4 small strokes already just this year.

    Sucks so bad watching him die this way. His body is pretty much his life and it's going away fast.

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