Eighty percent of hospitalized patients developed neurological problems, contributing very significantly to the number of deaths. One cause, “direct neuroinvasion by the virus” states that the virus got directly into the brain.Neurosurgeon Dr. Russell Blaylock wrote in May 2020 that “By wearing a mask, the exhaled viruses will not be able to escape and will concentrate in the nasal passages, enter the olfactory nerves and travel into the brain.” He was heavily criticized for this, but mostly by ignorant, non-medical individuals. ⁃ TN Editor
Introduction
As of 8 September 2020, severe acute respiratory syndrome coronavirus type 2 (SARS‐CoV‐2) has led to over 26.5 million confirmed infections and 875,000 deaths from coronavirus disease‐2019 (Covid‐19) worldwide.1
Like most infections caused by members of the coronavirus family, SARS‐CoV‐2 manifests itself with upper respiratory tract infections and flu‐like symptoms of varying severity.2 However, Covid‐19 is unique in its ability to cause a multi‐organ disease, with involvement of the central and peripheral nervous system in some individuals.
Indeed, a wide range of neurologic manifestations of SARS‐CoV‐2 infection have been recognized, and evidence of their severity and persistence is increasing.3–10 However, the frequency of those manifestations and associated risk factors remain unclear. We sought to characterize the incidence of neurologic manifestations, in patients with confirmed Covid‐19 and identify factors associated with the development of neurologic manifestations in hospitalized patients with both severe and non‐severe respiratory disease. Furthermore, neurologic manifestations, especially encephalopathy, have been associated with worse clinical outcomes in other systemic illnesses including sepsis and may even lead to significant disability.11, 12 Therefore, we sought to identify if encephalopathy was associated with greater morbidity in hospitalized patients with Covid‐19.
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